What to Do When You’re Told There’s Nothing Left to Try | David Fajgenbaum, Kiah Williams | TED

TED28:40Added Aug 30, 2026

What do you do when the world declares something impossible? When physician-scientist David Fajgenbaum was dying from a rare disease and social entrepreneur Kiah Williams was confronting the realities of economic hardship, they began asking a different question: What can I do today? In this conversation, they discuss how turning hope into action can drive meaningful change — one step at a time. (This conversation is hosted by The Audacious Project’s Alexandra Tillmann) (Recorded at TEDNext 2025 on November 10, 2025.)

Watch on YouTube →
Contributed by 刘嘉琪

Transcript

Transcript format
  1. 00:03Alexandra Tillmann: Alright, David, Kiah, thank you so much for being here.
  2. 00:09Let's jump in.
  3. 00:10Can you both share
  4. 00:12when you realized that life couldn't just happen to you,
  5. 00:17that you had to actively start choosing a path forward?
  6. 00:22David, I'll start with you.
  7. 00:23David Fajgenbaum: Sure.
  8. 00:24I might start back when I was a medical student.
  9. 00:27I had promised my mom that I would become a doctor in her memory
  10. 00:30when she passed away,
  11. 00:31when I was 19 years old,
  12. 00:32and in my third year of med school,
  13. 00:34I was really on my way to making that progress,
  14. 00:37helping patients in my mom's memory
  15. 00:38when I personally became critically ill with a disease
  16. 00:41called Castleman disease.
  17. 00:42I was so sick that I had my last rites read to me,
  18. 00:45I spent six months in the intensive care unit,
  19. 00:47and my doctors told me that we were out of options,
  20. 00:50but they gave me chemotherapy,
  21. 00:51seven different chemotherapies all at once.
  22. 00:53And amazingly, those chemotherapies worked.
  23. 00:56They saved my life, but what they also did
  24. 00:58is they opened my eyes up to this idea
  25. 01:00that none of those seven chemotherapies were made for my disease,
  26. 01:03but they saved my life.
  27. 01:05So when I relapsed a year later, my doctors told me,
  28. 01:07"We're out of options, you're going to die from this disease."
  29. 01:10I said, wait a minute, didn't you give me these seven chemotherapies
  30. 01:13that weren't made for my disease and they worked?
  31. 01:16How do we know there's not another drug out there
  32. 01:18that could help me?
  33. 01:19And so this sort of opened up my eyes.
  34. 01:21I eventually discovered another drug that could save my life,
  35. 01:24but opened my eyes up to this idea
  36. 01:26that even when the world thinks there are no more options, no more hope,
  37. 01:29sometimes there's a solution that's literally as close to you
  38. 01:32as your neighborhood pharmacy.
  39. 01:33Kiah Williams: I think for me, it was when I was young,
  40. 01:36my family just fell apart.
  41. 01:37And we were teetering at the edge of poverty.
  42. 01:40And I remember going outside, I grew up in West Philadelphia,
  43. 01:44I remember going outside one night and literally saying to myself, like,
  44. 01:49I have to be the one that saves myself,
  45. 01:54that creates a new path for myself.
  46. 01:55And so I'd always, you know, focused on school and trying to do well.
  47. 02:00But I made this decision at a young age to just say, like,
  48. 02:02I was like, I need to get out of here and I need to do something
  49. 02:06and have a better life than this for myself.
  50. 02:09And the only one who's going to do it is me.
  51. 02:12That obviously wasn't true,
  52. 02:14I had a ton of help from like, teachers, even my parents, etc.
  53. 02:17But I remember being very young, 15 years old, and saying, like,
  54. 02:22"I've got to do something different,
  55. 02:24I need to do something different and better"
  56. 02:26and was able to, like, work really hard, buckle down in school,
  57. 02:29got a full need-based scholarship to Stanford.
  58. 02:32And essentially that was the beginning of me recognizing, like,
  59. 02:35I could harness my own power and try to make something of myself.
  60. 02:41And I think fast forward years from then,
  61. 02:43when I was actually working in clinics, in medical clinics,
  62. 02:47and was going to be the first doctor in my family
  63. 02:49and would see patients who weren't getting better,
  64. 02:52doctor leaves the room,
  65. 02:54it's just me in the room as a health coach,
  66. 02:56talking to patients about whatever they want to talk about,
  67. 02:59and learning that sometimes people weren't getting the medicine
  68. 03:02that they needed because they couldn't afford it.
  69. 03:04So that's why their blood pressure is still high,
  70. 03:07their cholesterol is still high, their diabetes is not getting better.
  71. 03:10And I realized that I wanted to do something
  72. 03:12that could address that at a root level
  73. 03:14for those patients who were trying to take care of their health.
  74. 03:18And just all of these external factors were blocking their ability to be well.
  75. 03:23AT: You know, as you both talked about,
  76. 03:25our life is shaped by our circumstances, right?
  77. 03:29Some more formative than others.
  78. 03:31You nearly lost your life.
  79. 03:34And some we can control more than others,
  80. 03:37but they all contribute to where we head.
  81. 03:41As I shared, you know, these can be dramatic,
  82. 03:45or they can be small.
  83. 03:47David, you know, your near-death experience with Castleman's disease
  84. 03:51led you to become both patient and researcher really simultaneously.
  85. 03:55And Kiah, as you just shared,
  86. 03:58the economic resources of your family
  87. 04:01that you were born into really affected
  88. 04:03kind of, what you dreamed for your future.
  89. 04:06These are the realities of your lives, but you manage to use it
  90. 04:10for your creative fuel, for your energy.
  91. 04:13Can you talk a little bit about how you took those things out of your control
  92. 04:17and used them to expand rather than to contract,
  93. 04:22which I think can be a very natural experience for some people?
  94. 04:26KW: I think -- there's a really good quote that one of my co-founders used,
  95. 04:31and I love this because I think it so speaks to me,
  96. 04:35"sometimes motivation follows motion."
  97. 04:38Not the other way around.
  98. 04:40And so I think sometimes literally
  99. 04:41just by putting one foot in front of the other,
  100. 04:44you don't have to have 100 percent of the answer.
  101. 04:47You can have five percent of the answer.
  102. 04:49Just start moving towards that.
  103. 04:51And so I think when we think about this big issue,
  104. 04:53even of 30 percent of people in the US not being able to get medicine they need
  105. 04:59because it's just too expensive.
  106. 05:01We don't have to have all the answers to fix everything now.
  107. 05:04We can just start on the thing that we know to be true,
  108. 05:07which is this is a dumb problem,
  109. 05:09and we know that there's surplus that exists
  110. 05:11to actually meet some of that need.
  111. 05:13And let's start moving forward with that now.
  112. 05:15And I think a lot of that also, just like from my personal experience
  113. 05:19and just thinking about my own family and kind of where I came from,
  114. 05:23I mean, my dad always told me this growing up,
  115. 05:25he was like, you know, my grandfather wasn't literate.
  116. 05:28And people would ask him like, well, how does he function?
  117. 05:32And I remember someone asked specifically,
  118. 05:34how do you drive if you can't see street signs?
  119. 05:37And my dad told me that his father said to him,
  120. 05:39"I look at the stars."
  121. 05:41And so I'm like, if my grandfather can look at the stars to find his way
  122. 05:46and navigate through streets,
  123. 05:49what excuse do I have to not do everything I possibly can
  124. 05:53for the patients that we're serving, and to plot a better life?
  125. 05:58Look at the stars.
  126. 06:00AT: It's incredible.
  127. 06:01And David, how about you?
  128. 06:02DF: I love that.
  129. 06:04For me, I think that the moment that that drug sirolimus,
  130. 06:07which is the drug that ended up saving my life,
  131. 06:10the moment that drug started working for me,
  132. 06:12I started seeing my results improving, started feeling better.
  133. 06:15I just haven't been able to get this question in my mind.
  134. 06:18If this drug is working for me,
  135. 06:20how many more life-saving drugs are sitting at our local pharmacy
  136. 06:23that could treat more patients and more diseases today?
  137. 06:26And I think exactly as Kiah is saying, you know,
  138. 06:28once you see something like this, once you experience something like this,
  139. 06:32whether it's learning about access to medicines or the work we're doing,
  140. 06:36learning about the fact that there's all these hidden cures
  141. 06:39that are unmatched,
  142. 06:40you can't unsee it.
  143. 06:41Especially when you see the impact that it has on humans,
  144. 06:44patients that are alive because of these medicines.
  145. 06:46And so I think, to answer the question,
  146. 06:48once you see something like that,
  147. 06:50it's about continuing to push forward and say, OK,
  148. 06:52maybe this helped me, but can this help the person
  149. 06:55down the street from me?
  150. 06:56Can this help someone else in my community?
  151. 06:58And then when you start seeing that it can,
  152. 07:01you can just keep asking bigger and bigger questions.
  153. 07:03Can it help people all over the world?
  154. 07:05And I think that's so important in guiding us.
  155. 07:07AT: Kiah, you just were touching on something.
  156. 07:11You were talking about the fragility of healthcare across the country,
  157. 07:14which really led you to start Sirum.
  158. 07:18In your work, you often confront systems
  159. 07:21that are not easy to change
  160. 07:24or that aren't fair.
  161. 07:26And you've witnessed, as you shared,
  162. 07:29families that are making impossible choices
  163. 07:31between being able to afford medicine,
  164. 07:34being able to get food on the table for dinner.
  165. 07:38These are issues we're all hearing about every day on our news, too.
  166. 07:43How do you counsel others
  167. 07:45who see systems working against the greater good
  168. 07:50or perhaps are plagued by injustice,
  169. 07:53but wonder, do they really have the power to make any change?
  170. 07:58KW: I think that's a very timely question.
  171. 08:01What do you do in your own community?
  172. 08:02What do you do in this state, what do you do in the country,
  173. 08:05whatever level you're looking at?
  174. 08:07And I think Sirum has really shown me the power of getting out there
  175. 08:13and just getting stuff done.
  176. 08:15We started as a very ragtag,
  177. 08:17like, this started as a student project,
  178. 08:20and has grown now to the largest redistributor of unused medicine.
  179. 08:23But sometimes it's literally just picking up the phone
  180. 08:26and calling a local legislator.
  181. 08:27So, for example,
  182. 08:29we actually were able to launch a home-delivery pharmacy
  183. 08:31in the state of Georgia,
  184. 08:33but the way that that happened
  185. 08:34was literally we got an email from a retired person in Georgia,
  186. 08:39and we got one of these emails that was like,
  187. 08:41it was like all purple font.
  188. 08:42So we were like, how legitimate is this?
  189. 08:44Everyone knows those emails that you get in inbound to your like, hello@sirum.
  190. 08:49And we were like, this may or may not be legitimate.
  191. 08:51Concerned citizen that says, "Hey, how do I make this happen in my state?"
  192. 08:55Emailed us in, called his local legislator,
  193. 08:59got us a meeting with the chair of public health
  194. 09:03in the Georgia legislature.
  195. 09:05That was the beginning that was the spark.
  196. 09:07So I think we can actually trace back in every area that we're working
  197. 09:12in this country.
  198. 09:13It was usually just one person who was concerned.
  199. 09:16It was a concerned pharmacist who saw unused medicine.
  200. 09:19It was just a random person who read an article about us and said,
  201. 09:23"I want to do something, what can I do?"
  202. 09:25And we said, if you can get us a meeting with the state,
  203. 09:27that would be awesome.
  204. 09:29And like, from that moment of just them calling their legislator
  205. 09:33to say, "Hey, I want to see this program happen,
  206. 09:37we were able to make inroads.
  207. 09:38So I think that it can feel very --
  208. 09:41A lot of it is just unclear what is the path forward.
  209. 09:45Again, you don't have to know every step,
  210. 09:47but doing something rather than nothing,
  211. 09:48choosing action over apathy,
  212. 09:51I think it just bears out.
  213. 09:53And I've just seen this multiple times, the value of an email or a phone call,
  214. 09:57and what it can be to changing, fundamentally,
  215. 10:00the destiny of our organization,
  216. 10:03but also our ability to serve tens of thousands of more patients.
  217. 10:08AT: Incredible.
  218. 10:10David, I'll turn to you.
  219. 10:13Many people feel like they need permission
  220. 10:16or like, a dramatic wake-up call
  221. 10:18to chase their audacious dreams
  222. 10:22or really affect change.
  223. 10:26But what would you say to someone who senses this can't be all there is,
  224. 10:30you know, but isn't sure quite whether or how to show up?
  225. 10:35DF: Yeah, great question.
  226. 10:37I think that no matter what you're going through in your life
  227. 10:40or the challenges you're facing,
  228. 10:42I think it's worthwhile asking yourself, what am I hoping for every day?
  229. 10:46What am I wishing for?
  230. 10:47What am I praying for?
  231. 10:48Like actually reflect on the things that you're praying for, wishing for,
  232. 10:52and hoping for every day.
  233. 10:54And that can oftentimes tell you exactly what you should be doing,
  234. 10:57because whatever you're hoping for and you're wishing for,
  235. 11:00that is actually the inverse of what you should be doing.
  236. 11:03You know, what can you do today, tomorrow, and the next day
  237. 11:06to create the thing that you're hoping for,
  238. 11:08to solve the problem that you wish would be solved.
  239. 11:11And there are a lot of challenges that we face every day
  240. 11:13that feel insurmountable,
  241. 11:15and many that truly we have a hard time
  242. 11:17actually having an impact on.
  243. 11:19But there are also many problems in our lives
  244. 11:22that we're hoping for a solution for,
  245. 11:24that we actually have something that we can do
  246. 11:26to help to solve that problem.
  247. 11:28And as Kiah mentioned, it may be that we can call a state legislator,
  248. 11:33or maybe it's that we can post something on social media
  249. 11:35to raise awareness about a problem.
  250. 11:37But there are tangible things we can do.
  251. 11:39But I think it all starts at reflecting on what are you hoping for?
  252. 11:43What are you wishing for?
  253. 11:44And I think that's a great place to start with,
  254. 11:47what you should be doing every day.
  255. 11:48AT: Yeah, you call that, in your TED talk, actionable hope, right?
  256. 11:52That it's not enough to just hope for something more, to say,
  257. 11:55well, in six months or in a year, right?
  258. 11:59Maybe talk a little bit about that.
  259. 12:01DF: That's right.
  260. 12:02I've realized there's this circuit and it all starts with hope,
  261. 12:05you know, what are you hoping for?
  262. 12:06And that hope really needs to drive action.
  263. 12:09And if that hope drives action,
  264. 12:10what I found is it often will drive impact.
  265. 12:12And what does impact do?
  266. 12:13It gives you more things to be hopeful for, more hope.
  267. 12:16You create this incredible circuit.
  268. 12:18Hope, action, impact, leads to more hope, action, impact.
  269. 12:21And all of a sudden, years later,
  270. 12:23you're sitting here with these two amazing people and all of you
  271. 12:26and able to share about an organization, Every Cure,
  272. 12:28that's saving lives of patients all over the world.
  273. 12:31But it all starts with that first hope and turns to action and impact.
  274. 12:35AT: I know we're going to talk about a lot today, but, you know,
  275. 12:38for Every Cure and Sirum, like, how can people be part of it
  276. 12:42or support the work that you're doing?
  277. 12:45DF: Sure, I'm happy to start.
  278. 12:46Yeah, absolutely.
  279. 12:48So many of us in this room have received medicines
  280. 12:52for diseases that they're not approved for to treat us.
  281. 12:56It's called off-label use.
  282. 12:57In fact, 20 to 30 percent of all prescriptions
  283. 12:59in the US every day are off-label.
  284. 13:01So doctors are trying drugs for diseases they're not intended for.
  285. 13:04Unfortunately, it happens very randomly
  286. 13:06and there are a lot more opportunities for those drugs to be used systematically.
  287. 13:10But it's just not profitable in our system to find a new use for an old drug.
  288. 13:14Eighty percent of drugs are generic,
  289. 13:16so unfortunately, the system isn't built for this,
  290. 13:18to find new uses for medicines.
  291. 13:19But the reason I share that as background
  292. 13:21is that that means that most of you all have received a drug
  293. 13:24for a disease it wasn't intended for, and maybe it helped some of you.
  294. 13:28You can go to everycure.org/ideas
  295. 13:29and you can tell us about a drug that you've received
  296. 13:32that maybe has helped you, that we can look into.
  297. 13:34We can look into our AI platform to see how is it ranking
  298. 13:37versus all of our other repurposing ideas.
  299. 13:39Second is that you can help to support us financially.
  300. 13:41We run large clinical trials that are very expensive,
  301. 13:44and we want to reach patients all over the world.
  302. 13:46And finally, awareness raising is really important.
  303. 13:49We find treatments for diseases that we never would have imagined,
  304. 13:52like lidocaine for breast cancer
  305. 13:54or DFMO for Bachmann-bupp syndrome.
  306. 13:57And amazingly, the problem for a lot of these medications is just awareness,
  307. 14:01just getting that drug to the patient.
  308. 14:03It's a matter of letting patients and doctors know.
  309. 14:05So helping to spread the word about our work at Every Cure.
  310. 14:08KW: For us, there is an opportunity, if you have --
  311. 14:11in some instances,
  312. 14:12individuals can actually donate their unused medicine
  313. 14:15as long as they're in sealed containers, unexpired.
  314. 14:19So there's an opportunity for you to potentially donate.
  315. 14:22The other thing I would just say is, this is TED.
  316. 14:24Like, y'all are well-resourced, well-connected individuals.
  317. 14:28If you want to see us come to your state to bring a full solution
  318. 14:34for medication access to your state, reach out.
  319. 14:37AT: You know, going back to what David was talking about, actionable hope,
  320. 14:40I think that's such an important thread.
  321. 14:44And Kiah, we were talking yesterday,
  322. 14:47and I've heard you say before that it's a privilege to do hard things.
  323. 14:52Kiah also has a new baby,
  324. 14:54so she's in the thick of doing hard things right now.
  325. 15:00And something that you also have said is that,
  326. 15:04really thinking about short-term pain for long-term gain.
  327. 15:08So maybe talk a little bit, Kiah,
  328. 15:10about how you kind of, rationalize those feelings
  329. 15:14of the pain and the gain.
  330. 15:16KW: So like, hope is a tough concept for me
  331. 15:18because I am ...
  332. 15:21I am a probably realistic, pragmatic pessimist.
  333. 15:26Like, I don't think anyone who's ever worked with me
  334. 15:28would say "Kiah is a hopeful, optimistic human."
  335. 15:31Which is kind of a weird thing to say,
  336. 15:33considering I'm doing social entrepreneurial work
  337. 15:36and trying to have impact in this world.
  338. 15:38So like, why am I doing this?
  339. 15:39And how do I get up every day and continue to do it?
  340. 15:42And I think a lot of it comes down to like, you know,
  341. 15:46when you are having personally experienced,
  342. 15:48when you are living at the edge
  343. 15:50and you're like, I've just got to put one foot in front of the other.
  344. 15:53I've got to make sure I have what I need.
  345. 15:55I have to make sure there's a roof over my head.
  346. 15:57I have to make sure there's electricity because the electricity got cut off.
  347. 16:01Like, you're not necessarily thinking about the hopes and dreams of the future
  348. 16:05that you want to have.
  349. 16:06You are thinking about living today and making to tomorrow.
  350. 16:09But I think that in and of itself, I've realized, is a form of hope,
  351. 16:13because you do not just lay down and die.
  352. 16:16Candidly, like.
  353. 16:18And this is something I say to myself
  354. 16:19because I am not an optimistic person.
  355. 16:21I'm not a very hopeful person.
  356. 16:23"Well, Kiah, you have options
  357. 16:24and hopefully you choose to make this world a better place
  358. 16:27and to keep going."
  359. 16:28And I think what you referenced around, like,
  360. 16:31how do I make this all work in my head,
  361. 16:33is, at the end of the day,
  362. 16:36now that I am not in that situation where I am worried about basic needs,
  363. 16:42like, it's such a privilege to be able to choose the hard things in your life.
  364. 16:47For so many people in this world that is not a choice that they have.
  365. 16:51That thing is sitting right in front of them,
  366. 16:53staring at them every single day.
  367. 16:56So the fact that I have food on the table, good health insurance,
  368. 16:59a roof over my head,
  369. 17:02I get to now choose
  370. 17:04what are the things that I'm going to take on that are hard.
  371. 17:08And so like, I reflect on that,
  372. 17:09especially now being on a stage like this in a room like this,
  373. 17:13what a privilege it is for me to choose hard things
  374. 17:17and to go out and tackle those.
  375. 17:19And all of us in this room,
  376. 17:21I think mostly, probably, have the ability
  377. 17:24to choose the hard things that you're going to tackle in your life.
  378. 17:28So you can choose career, you can choose to start a new job,
  379. 17:31you can choose to start a new organization.
  380. 17:33Like, these are all choices that we have, and it's a privilege of choice.
  381. 17:37And so I think for me, that is what gives me more hope.
  382. 17:41And that lights a fire under me of this idea of every day I get to wake up
  383. 17:45and choose to go out into this world
  384. 17:47and tackle some of these systems of oppression.
  385. 17:51Systems of inequality.
  386. 17:53And so like, what a beautiful life that is,
  387. 17:56to be able to wake up every day
  388. 17:57and be at Maslow's hierarchy of need at the top,
  389. 18:01working on self-actualization.
  390. 18:04AT: David, for people who are navigating
  391. 18:08some of that crossroads that you're talking about, a big change,
  392. 18:11maybe it's you want to start an organization or change jobs,
  393. 18:17but for those of us who might be in that place
  394. 18:19but feeling a little bit stuck,
  395. 18:21what small everyday choices or mindsets
  396. 18:26do you share with people to kind of help them move forward
  397. 18:29or build like, a more meaningful path?
  398. 18:31DF: I think there's three things that can really help you
  399. 18:34during a really tough time.
  400. 18:36And I learned this from the six months that I spent in the intensive care unit
  401. 18:40when I was dying from my disease, Castleman's.
  402. 18:44And the first is that you have to have a vision for what you're fighting for.
  403. 18:48So you have to be able to actually see what is it that you want
  404. 18:52and that you're wishing and hoping for.
  405. 18:53So for me, I was wishing and hoping for a family
  406. 18:56with my girlfriend at the time, Caitlin.
  407. 18:58I was wishing and hoping that I would be able to find drugs
  408. 19:01in memory of my mom and treat patients in her memory.
  409. 19:03That vision was so important for me as I was struggling to survive
  410. 19:07for those six months.
  411. 19:09The second is that you have to have an amazing team of people by your side.
  412. 19:13My sisters literally held both of my hands
  413. 19:16eight hours a day for those six months,
  414. 19:18giving me the strength that I needed.
  415. 19:20My dad sat with me, my girlfriend was there with me as well.
  416. 19:23They provided strength and support.
  417. 19:24And of course, when you think about it from a professional perspective,
  418. 19:28the team that you have around you is everything, right?
  419. 19:30It's so important, it is truly everything.
  420. 19:32And the third is that you have to take things one step at a time.
  421. 19:36If someone had come to me at the beginning of the six-month period
  422. 19:39and said, "You're going to suffer the most unbearable pain you've ever felt,
  423. 19:42you're going to be on the brink of death for six months.
  424. 19:45You're going to say goodbye to your family."
  425. 19:47I would have said, there's no way I have the strength
  426. 19:50to make it for six months.
  427. 19:51I would have said, "Where's the white flag?"
  428. 19:53No way I can do that.
  429. 19:54But taking the approach of one step and one breath at a time
  430. 19:57helped me so much.
  431. 19:58I remember there was one point, about 11 weeks into that illness,
  432. 20:02where my doctors told me that we were out of options,
  433. 20:05and I started slowing my breathing.
  434. 20:07It was so painful to breathe and I was starting to let go.
  435. 20:10And I remember looking up at my sister and everyone else had said goodbye,
  436. 20:15you know, said goodbye to all the people that I love.
  437. 20:18And my sister looked at me and said, "Just breathe, Dave."
  438. 20:21And I remember hearing that
  439. 20:22and I was like, "You know what?
  440. 20:24I can do maybe one or two more breaths, let's go."
  441. 20:26And I did a couple more.
  442. 20:27I can do a minute of this, I can do an hour of this.
  443. 20:30And those couple of hours to couple of days
  444. 20:33were the difference for the time we needed
  445. 20:35for the chemotherapy to kick in to save my life.
  446. 20:37And so I think with all these challenges that we face,
  447. 20:40if you can have the vision for the future,
  448. 20:42the support by your side,
  449. 20:43and then really take things one step or one breath at a time,
  450. 20:46I think we can overcome so much.
  451. 20:48AT: Resilience is a topic that's been touched on a lot
  452. 20:51over these last couple of days,
  453. 20:52and I think that the perception often is that social entrepreneurs
  454. 20:58or leaders like you are always full of hope,
  455. 21:01like, always ready to go forward and conquer more.
  456. 21:06Like, is that how it feels to you?
  457. 21:08Do you always feel that way?
  458. 21:10KW: I think I already said no.
  459. 21:12I'm a very pessimistic human.
  460. 21:16In a lot of ways, on a daily basis.
  461. 21:18But I am, it's interesting,
  462. 21:20I don't know that I have always hope.
  463. 21:22I know that I have faith.
  464. 21:24And I know that I have faith, weirdly, in this country.
  465. 21:28I have faith in humanity.
  466. 21:30And I think going back to what is the vision that you want to see
  467. 21:34and what is the world you want to live in,
  468. 21:36like, it's much better for me,
  469. 21:39and I can wake up and be happy and recharged thinking about this world
  470. 21:44and humanity as a race that is ultimately going to save itself
  471. 21:47than it is to think about this country or humanity
  472. 21:51as a race that's going to implode and destroy itself.
  473. 21:55AT: It's helpful to hear.
  474. 21:56KW: So ... I think, yeah, a lot of us are tired,
  475. 22:00like, people are tired.
  476. 22:03And at the same time, like, this is it.
  477. 22:07Like, I think you had mentioned previously this concept
  478. 22:10of short-term pain, long-term gain.
  479. 22:12I think many of us are in this room or watching this talk,
  480. 22:16because you've had a lot of really cool opportunities to be successful.
  481. 22:20And I think what we learned from that is delayed gratification oftentimes.
  482. 22:25To say, OK, you put in these hours studying, you do schooling,
  483. 22:29you wait for that promotion, you work hard,
  484. 22:31you put your head down and you grind to get to some next step.
  485. 22:34And that is great, that is awesome.
  486. 22:37At the same time, I want to just raise the alarm that we cannot defer life
  487. 22:43and we cannot think about like, well, you know,
  488. 22:46right now is really challenging,
  489. 22:49hopefully five years from now to be better.
  490. 22:52I think that there is a time in which you have to decide for yourself,
  491. 22:55when am I in that grind-it-out, delayed gratification.
  492. 22:59I'm going to just put in the time and then pop my head out later.
  493. 23:03And when are you going to say to yourself, like, this is my life now?
  494. 23:07How am I going to make decisions and take new actions that change my life,
  495. 23:11my family, my community, my world for the better?
  496. 23:15AT: I find that so powerful.
  497. 23:17David, anything you want to add to that?
  498. 23:19DF: I just completely agree with Kiah in everything she said.
  499. 23:23I think I probably fall on the end of the spectrum of being
  500. 23:26maybe a little bit more optimistic and hopeful.
  501. 23:28Which I think is great,
  502. 23:30I think the important thing is that it's finding some balance.
  503. 23:33I think it's important that we get to work together and do tough things.
  504. 23:37But I think that what I would say is that I sort of, you know,
  505. 23:42have the mindset of what's possible in terms of treating patients
  506. 23:45with horrible, deadly diseases.
  507. 23:47And I get a chance to see people that said goodbye to their family,
  508. 23:50that were on their last legs
  509. 23:52and were able to save their life
  510. 23:54with a medicine that wasn't made for that disease.
  511. 23:56And it's hard for me to put it into words.
  512. 23:59Just what that means when you get to see someone come back,
  513. 24:03literally, from the dead,
  514. 24:04where you literally get to see someone walk their daughter down the aisle
  515. 24:08on their wedding day,
  516. 24:09get to hear their child speak to them for the first time.
  517. 24:13These things are so powerful and they give you so much energy.
  518. 24:17It's hard to describe.
  519. 24:19I think another piece of this is
  520. 24:21when you say goodbye to people you love, and you start to wake up
  521. 24:24and you're like, oh my gosh, I got another day.
  522. 24:26Like, this is incredible.
  523. 24:28It gives a glow to life that's hard for me to overemphasize.
  524. 24:32At the same time,
  525. 24:34we also have patients that we're not able to help
  526. 24:36and patients where we try everything for them
  527. 24:38and they still die from their disease,
  528. 24:40diseases that we're working on so hard,
  529. 24:43and we want treatment so bad and we just can't find them.
  530. 24:46And so I think that when you bring all those together,
  531. 24:49it's the excitement of life and the fact that we're all here
  532. 24:52and it's just amazing,
  533. 24:54the excitement of being able to help people that shouldn't be here,
  534. 24:57that are living what we call overtime,
  535. 24:59but it's also sitting with the pain of the patients we're not able to help,
  536. 25:02sitting with the pain of the diseases that we're not able to treat yet,
  537. 25:06and having that pain drive further action.
  538. 25:09AT: What is one thing that you would leave people with?
  539. 25:15Or like, an action that people can take to start to like make change
  540. 25:19in their life starting today?
  541. 25:21Kiah, I'll start with you.
  542. 25:23KW: I think we're in an incredible moment
  543. 25:25where thinking about what really matters to you,
  544. 25:28what really matters, not the things --
  545. 25:30There's a million things that everyone says that they care about, right?
  546. 25:33Because, like, to be a good human, to be a good person,
  547. 25:36you must care about a lot of things.
  548. 25:38You must do all the things, you must vote, you must recycle.
  549. 25:41You must go to see your dentist every six months.
  550. 25:43Like, there's all these things that we all have to do.
  551. 25:46I think there's too much.
  552. 25:48There's so many things.
  553. 25:49It's so hard to feel like you are a good person
  554. 25:52that is doing good things.
  555. 25:55And I think this is a time -- I've really been thinking about this
  556. 25:58because I have a new priority, which is I have a child now.
  557. 26:01It's how do I focus on the things that actually really matter?
  558. 26:06And for me, it’s understanding more authentically for myself,
  559. 26:12what are the things that, like --
  560. 26:14for me, it's again, it's like, what are the things that bother me?
  561. 26:17What are the things that anger me,
  562. 26:19what are the things I'm excited about?
  563. 26:20Like, for me, it's all about the strong emotions that come out
  564. 26:23and how do I focus my life and my work and my mission on impacting those.
  565. 26:29And it's going to have to be, for me, the way I choose to do that,
  566. 26:32is going deep in a couple areas and having to maybe say,
  567. 26:36I maybe didn't go to the dentist in the last six months
  568. 26:39and like, I'm OK with that.
  569. 26:41Like, maybe I'm taking a break from some of these things
  570. 26:44because I want to focus on these others.
  571. 26:46So I think it's really just understanding for you
  572. 26:48what are the things that actually just deeply matter
  573. 26:50and taking action on those
  574. 26:52because it's the recognition you can't do everything.
  575. 26:54And I'm a person who wants to do everything.
  576. 26:56And so I think rather than being really sad about that,
  577. 26:59it's using that as the empowering statement to myself
  578. 27:02to say, I can't do everything but the things I'm going to do,
  579. 27:04I'm going to do really well,
  580. 27:06I'm going to be really focused
  581. 27:07and I'm going to see impact in those areas.
  582. 27:10AT: But it is very important to go to the dentist every six months,
  583. 27:13don't forget that.
  584. 27:15David, just quickly.
  585. 27:16DF: Sure, so, completely agree with Kiah's points.
  586. 27:19And one way that I've sort of framed this
  587. 27:22in a way that's been really helpful for me,
  588. 27:24is that I've considered the moment that I nearly died for the first time
  589. 27:28to be the start of my overtime.
  590. 27:29And overtime is a sense that many of us can relate to.
  591. 27:32So think about at the end of a sporting event
  592. 27:35where your game goes into overtime,
  593. 27:37and if you're playing in one of those games,
  594. 27:40it can be really scary to be in overtime
  595. 27:42because like, at any minute, the game could end,
  596. 27:44if you make a mistake in overtime, the game is over.
  597. 27:47Make a mistake in the first half the game, you can make up for it.
  598. 27:50So overtime can be really scary.
  599. 27:52But overtime can also be really clarifying.
  600. 27:54When you're in overtime,
  601. 27:56you focus only on the things that are most important to win,
  602. 27:59whatever that sporting event is.
  603. 28:00And so I found for me
  604. 28:02that I've been in the state of overtime now for 15 years,
  605. 28:04I guess I'm in my fifth overtime by now.
  606. 28:07But in this overtime, it helps me to sort of cut out the noise,
  607. 28:10the things that I don't care about, the things that aren't important to me,
  608. 28:14and to just focus on the things that are really important to me.
  609. 28:17And so I think that I've, when I was 25,
  610. 28:19sort of first realized that we're all in overtime.
  611. 28:23But the truth is, we're all in overtime.
  612. 28:26And, you know, none of us know how long our overtime is going to go for.
  613. 28:29But all of us have the ability to make the most of every second in overtime.
  614. 28:33AT: What a great way to end.
  615. 28:34David, Kiah, thank you so much for a great conversation.
  616. 28:37(Applause)