How AI Is Changing Healthcare for Patients & Doctors | Dr. Fei-Fei Li & Dr. Andrew Huberman
Dr. Fei-Fei Li and Dr. Andrew Huberman discuss how artificial intelligence is transforming scientific discovery and healthcare, focusing on AI's ability to s...
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AI in Healthcare & Biology
- 00:00Since uh you're here, I'm going to go
- 00:02next to something that I think most
- 00:03everybody would agree would be a
- 00:05wonderful thing if it existed and it's
- 00:08already starting to happen, which is the
- 00:10use of AI to augment health discovery,
- 00:13treatment of disease and so on. So using
- 00:16the AlphaGo example from before and
- 00:18people surely still remember the cat
- 00:21example, those just follow certain
- 00:23rules. Alph Go is very complicated set
- 00:25of rules, but if you learn them, there's
- 00:27a constrained set of rules.
- 00:29With the cat, it seems unconstrained,
- 00:32like infinite possibilities, but it's
- 00:33constrained enough that machines and
- 00:35humans can learn it really well.
- 00:37When you start getting into medicine,
- 00:40there are rules of medicine. There are
- 00:42rules of science. You have a question,
- 00:44you pose a hypothesis, you test the
- 00:46hypothesis, you try and rule out your
- 00:47hypo and so on like the the scientific
- 00:49method. And in medicine, every field has
- 00:52its methods. We observe, we observe
- 00:55disease, we observe who recovers, we
- 00:57have a case report, we do a randomized
- 00:58control trial. So there are rules and
- 01:00the internet knows these rules. So LLMs
- 01:02can be used to mine health information
- 01:04very well because there are constrained
- 01:06rules. But I think you and I both know
- 01:09because I also consider you a biologist
- 01:11that the rules of biology are still
- 01:14revealing themselves to us. Which is not
- 01:16to say that the dermatologists,
- 01:17neurosurgeons, and oncologists don't
- 01:19know what they're doing, but they're
- 01:21doing what they're doing within a
- 01:22constrained set of rules that they
- 01:23learned. And even if they continue to
- 01:25learn and update them,
- 01:27it's every month it seems now that a
- 01:29discovery comes out that violates the
- 01:31rule. Like I learned that action
- 01:33potentials are unitary. They always look
- 01:35the same. You either fire or not.
- 01:37But there was a paper not but 12 years
- 01:39ago that showed that the shape of an
- 01:41action potential can vary quite a lot.
- 01:42It was published in Nature. Mhm.
- 01:45Everyone saw it and then no one wanted
- 01:46to deal with it.
- 01:47It's just too much. It changes the rule.
- 01:50Neurons are supposed to be either graded
- 01:52or all are one. And the all I mean it's
- 01:54in every single textbook. So now if I
- 01:56take a bunch of neural activity and I
- 01:58give it the rule, oh well you know
- 02:00action potentials can be big, they can
- 02:01be small in the same neuron. It
- 02:03completely confuses everything we
- 02:05understand about neuroscience
- 02:07and it just our understanding of the
- 02:08brain just breaks down to zero. Yeah.
- 02:10But if you gave AI the rule that it
- 02:12could be, you know, a hundred different
- 02:14shapes of this signal, well, AI could
- 02:17probably do a lot more than even the
- 02:20very very best graduate student at dare
- 02:22I say Stanford or to be fair MIT or
- 02:24Caltech. I don't think it can do it and
- 02:28it can do it like in the duration of
- 02:29this question, which admittedly is a bit
- 02:31long. So, I'd like to get your thoughts
- 02:33on how is it that humans in health care,
- 02:36the general public and AI can
- 02:38collaborate to help solve disease and
- 02:41ideally come up with new rules for
- 02:43discovery so that we can finally
- 02:45understand our biology at a level that
- 02:47can really change the course of humanity
AI for Scientific Discovery
- 02:50for the better.
- 02:50Yeah. No, Andrew, this is probably
- 02:53perhaps you touch one of the most
- 02:55exciting usage of AI, which is
- 02:57scientific discovery. And in the case of
- 03:00biio medicine, you know, scientific
- 03:02discovery directly connects to human
- 03:04health and diseases, I think we're we're
- 03:08ready for complete re rewriting of how
- 03:11scientific discovery can be done because
- 03:14for ages, I don't even know how long, it
- 03:17relies on smart humans retaining what
- 03:20they have learned from other smart
- 03:22humans and and and doing things at the
- 03:25speed of our own muscles, I guess, you
- 03:28know. Most likely of course there's like
- 03:32super colliders and and all that but by
- 03:34and large the the ways of doing
- 03:37scientific discovery
- 03:40human brain or scientists brain are the
- 03:43only central character in this process.
- 03:48Now we have a new tool whose brain that
- 03:52can retain humongous amount of
- 03:56information can help us synthesize
- 03:58knowledge can go across disciplines in
- 04:01ways that you and I cannot go. So for
- 04:04example we happen to be both in the
- 04:06vision neuroscience AI domain.
- 04:10I know nothing about you know oactory
- 04:14zero like I don't even know how to spell
- 04:16most of probably the these words in that
- 04:18our colleagues know right so it's so
- 04:21hard for our brain but now we have a
- 04:24tool that can break open so so I think
- 04:27that we need to change we need to use
- 04:30this tool we absolutely I I was just
- 04:33thinking 150 or I don't know exactly
- 04:36when years ago we electricity
- 04:40changed everything in in in our life,
- 04:44right? I'm sure that's a moment we were
- 04:47thinking about how
- 04:50the changes, the opportunities, the
- 04:52scary moment. I think we have to come to
Using AI for Personal Diagnosis
- 04:55reckon that scientific discovery is one
- 04:59of the most exciting opportunity for AI
- 05:04and for health, right? How information
- 05:06can be synthesized, how information can
- 05:08be presented not only to clinicians but
- 05:12also to patients and how patients can
- 05:15participate in that process from
- 05:17diagnosis to treatment is also there's
- 05:21just so much we can do now.
- 05:24Yeah. I mean AI I won't say AI is better
- 05:27than all doctors but AI was able to
- 05:30disambiguate vertigo from low blood
- 05:33pressure for me a few months back and
- 05:36one of the people who got it wrong is a
- 05:39ENT who works on the vestibular system.
- 05:41What information did you provide just
- 05:43your subjective?
- 05:44My subjective experience over a day or
- 05:47two.
- 05:47Okay. Um, turns out it was a medication
- 05:49that a doctor had prescribed me that I
- 05:51had a like a mild but adverse event. And
- 05:54it's a weird thing to step and feel like
- 05:56the whole world's dropping down and then
- 05:58kind of spinning and I thought, "Oh my
- 05:59goodness, this is like feels like
- 06:00vertigo." But I remember dizzy and
- 06:02lightheaded or different. So I started
- 06:04like looking into that and then and um
- 06:06sure enough it was a it was a blood
- 06:08pressure issue. It brought brought my
- 06:10blood pressure, excuse me, down too low.
- 06:12And but I consulted we know some smart
- 06:15doctors. Um none of these were at
- 06:16Stanford. I will say that this is the
- 06:18truth. But it was
- 06:19we should just be intellectually honest.
- 06:21But it's just remarkable. And when I ran
- 06:22it back to them, they were like, "That's
- 06:24really incredible." You know, had you
- 06:25not been on the phone with me and in my
- 06:26clinic, I would have been able to do
- 06:28some additional testing to be fair. But
- 06:30this was zero cost. It took a morning to
- 06:33know if I drank some uh electrolytes at
- 06:37what I would have thought would be
- 06:38excessive level that by two hours later,
- 06:42I would be fine. Now, of course, there's
- 06:43the possibility of a placebo effect
- 06:45here, but two hours later, I was fine.
- 06:48And so, it's also very consoling to the
- 06:50patient
- 06:51to have this. And so, it's not to say
- 06:53don't go to a doctor, but it it's
Robotic Surgery & AI Collaboration
- 06:55incredible. I mean, this exists now.
- 06:56The doctor can use this tooling. By the
- 06:58way, I have a very interesting example.
- 07:01You know that we have to reschedu this
- 07:03uh our conversation because my father
- 07:06was going through a surgery right at
- 07:08Stanford uh with an incredible surgeon.
- 07:11But the surgery was done by a robot, the
- 07:14Davinci robot system because it was a
- 07:17liver surgery and the surgeon,
- 07:19incredible surgeon was driving the
- 07:21robot. So it was a deep human machine
- 07:25collaboration. After the surgery, I
- 07:27asked the surgeon, I said, "Do you
- 07:30imagine if say you've done a million,
- 07:33which is impossible for a surgeon, but
- 07:35human surgeon, but let's collect all of
- 07:38human surgeons uh for for this liver,
- 07:41this type of liver surgery data. Can we
- 07:45possibly train a automatic AI to do
- 07:49this?" The answer was not clear. So we
- 07:53went a little bit down the rabbit hole
- 07:55because liver is a very complicated
- 07:57organ. It's extremely vascular. It has a
- 08:00lot of vessels and everybody's liver is
- 08:04very different. So given the reality of
- 08:08how many patients undergo liver surgery
- 08:11per year, even if you aggregate um the
- 08:15world's liver patient um surgeries, you
- 08:18might not have enough data to train
- 08:21these algorithm. So this speaks of a
- 08:24very important fact that um AI learns
- 08:27from patterns. When the patterns are not
- 08:30abundant,
- 08:32then we have to be careful. We have to
- 08:33know how to use AI or how not to use AI.
- 08:37You know in this case that having a
- 08:39human collaborating with the robot is
- 08:42way better than a underlearned robot
- 08:45doing the surgery by itself. But the
- 08:48same issue might be true for surgeons
- 08:49because how many surgeries a surgeon can
- 08:52get trained on. So these are
- 08:54opportunities that humans and AI can
- 08:57totally collaborate with and might
- 09:00reveal the best result. Right now the
- 09:03future remains to be seen. Can we create
- 09:05a artificial simulation of a liver that
- 09:08we can now train infinite possibility?
- 09:11These are all incredibly open scientific
- 09:15possibilities that is waiting ahead of
- 09:18us. But then there are
- 09:21uh situations like your situation where
- 09:24the vertigo versus low blood pressure
- 09:27probably have been reported so many
- 09:29times that in the database there's
- 09:33enough of that that AI has learned that
- 09:36so we can then now take advantage of
- 09:38that for people who don't have immediate
- 09:41access to doctors.
- 09:43Amazing. Is your father's surgery went
- 09:45okay?
- 09:45It did. It actually
- 09:47lost
- 09:4910x less blood than a typical surgery uh
- 09:54thanks to the laparoscopic capability of
- 09:57a robot.